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Piracetam Chem., Moleculure Structure

From: dyer@spdcc.com (Steve Dyer)
Subject: Re: Piracetam molecular structure?
Date: Thu, 30 Mar 1995 15:07:51 GMT

El Poeta, an33392@anon.penet.fi, wrote:
   >Anybody know the molecular structure of Piracetam (Nootropil)?
   >The chemical name is 2-oxo-pyrrolidine acetamide, but I don't know the
   >2-oxo-pyrrolidine structure either.  It seems that it is very similar to
   >the amino acid pyroglutamate (2-oxo-pyrrolidine carboxylic acid).

Correct. Which is why you often see pyroglutamate for sale in health food stores in the US. The idea
is that it's supposedly a nootropic too. Europeans seem to be a lot more convinced of piracetam's
utility than US researchers.

Piracetam

   H2C---CH2
         |      |
        C    CH2
      / / \   /
     O   N
            |
           CH2-CONH2

Pyroglutamate

   H2C---CH2
         |      |
        C    CH-COOH
       / / \  /
      O  N
           H