Make your own free website on Tripod.com
Narcolepsy and Cataplexy(also Catalepsy):

GHB: What is; (Description and other information below)
GHB (aka Gammahydroxybutyrate aka sodium gamma-hydroxybutyrate)

GHB, or gamma-hydroxybutyrate, is a normal component of mammalian metabolism. It is found naturally in every cell in the human body and is most properly considered a nutrient. In the brain, the highest amounts are found in the hypothalamus and basal ganglia [Gallimberti, 1989]. GHB is found in greater concentrations in kidney, heart, skeletal muscles, and brown fat tissues [Chin and Kreutzer, 1992]. It is believed to be a neurotransmitter, although the jury is still out as to whether it exhibits all of the properties required for fulfillment of this function [Chin and Kreutzer, 1992]. It is both a metabolite and precursor of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid, or gamma-aminobutyrate), another nutrient to which it bears a close structural relationship. GHB, however, does not act directly on GABA receptor sites [Chin and Kreutzer, 1992].
It has been used in earlier years for its beneficial effects in patients with narcolepsy. There have been however, a few cases where the patient suffered health problems, and in one case known died while under a doctors care. It is this and other situations outside of its use with narcolepsy that have given some in the medical health field concerns on whether to reclassify GHB as a controlled substance.



References:     1. Gallimberti L, Gentile N, Cibin M, Fadda F, Canton G, Ferri M, Ferrara SD and Gessa GL. Gamma-hydroxybutyric acid for treatment of alcohol withdrawal syndrome. The Lancet, 787-9, 30 September 1989.  2.  Chin MY, Kreutzer RA and Dyer JE. Acute poisoning from gamma-hydroxybutyrate in California. West J Med (United States). 156(4): 380-4, April 1992.


Caution: GHBis a Controlled Substance in "some" states. Always seek the advice of a Attorney before ordering.


For more information visit::

A.) NCADI Website; Q&A on GHB                 B.) Stanford University;  GHB
C.) Michael Cohn's website on GHB            D.) FAQ Section for GHB
E.) GHB: side effects, legal status info        F.) GHB and the treatment of narcolepsy
G.) [the] GHB Information Site                    H.) Abstracts: GHB and Narcolepsy
I.) Lycaeum's Links and Resources            J.) CERI; about GHB
K.) GHB: Gamma-OH                                   L.) GHB info.com (alot of info btw)
M.) "Another GHB Page"(Recommended)    N.) CERI: GHB PAGE (you should read this)
O.) GHB: the Antidepressant: Gamma-OH    P.) GHB - New Perspectives (NC-17 Page btw)
Q.) HMB, or beta hydroxy beta methylbutyrate; virtually identical to GHB. But patented.
R.) Dumb on Drugs: GHB & the FDA



GHB: Testimonials & misc Experiences:
*WARNING*PART 1: Read no further until you review this ladies website "Click Here"
                        PART 2: Now got this page. Written by a webmaster and sent to the above author.
 
A.) GHBinfo: Testify            B.) Miscellaneous          C.) Detailed accounts

Studies performed on "GHB": (a.k.a. Gammahydroxybutyrate)
A.) "Pharmacokinetic effects of gammahydroxybutyrate (GHB) in narcoleptic patients"
(Note: PDF File. Acrobat Reader Required) "Summary in regular format here"
B.) "Narcoleptics - methylphenidate: a comparison of sleep, MWT and performance measures"
C.) "Simultaneous stimulation of slow-wave sleep & GH secretion by GHB in normal young Men"
D.) "Non-response of a case of fatal familial insomnia to gamma hydroxy butyrate"
E.) "Trigger of paradoxical sleep w/ GHB in the rat, blocked w/ GHB receptor antagonist..."
F.)"Rewarding properties of GHB: an evaluation through place preference paradigm"
G.) "Gamma-hydroxybutyric acid decreases intravenous cocaine self-administration in rats."
H.) "GABAB receptors..., excitatory synaptic transmission in rat supraoptic nucleus in vitro."
I.) "Gamma hydroxybutyrate is not a GABA agonist"
J.) "Gammahydroxybutyrate and narcolepsy: a double-blind placebo-controlled study"
K.) "Effects of gamma-hydroxybutyrate on the sleep of narcolepsy patients: a double-blind study"
L.) "Effects on nocturnal & diurnal sleep; : REM sleep-triggering mechanisms"
M.) "GHB--new hope for narcoleptics?"
N.) "GHB versus placebo in treating narcolepsy-cataplexy: double-blind subjective measures"
O.) "Nocturnal GHB. Effect on periodic leg movements & sleep organization of N-patients"
P.) "Treatment of narcolepsy with GHB. A review of clinical and sleep laboratory findings"
Q.) "Nocturnal sleep of narcoleptic patients: revisited"
R.) "The effects and effectiveness of gamma-hydroxybutyrate in patients with narcolepsy"
S.) "The treatment of narcolepsy-cataplexy with nocturnal gamma-hydroxybutyrate"
T.) "The effects of gamma-hydroxybutyrate on sleep"
U.) "Tiapride-induced catalepsy is potentiated by gamma-hydroxybutyric acid administration"
V.) "Modulatory effects of gamma-hydroxybutyric acid on a GABA(A) receptor..."
W.) "Review of the effects of gamma-hydroxybutyric acid with recommendations for management"
X.) "Seven cases of gamma-hydroxybutyric acid overdose"

NOTE: My purpose for providing so many links and references for this Drug is that if used without a Doctor trained in its proper use, one may find themselves dialing 9-1-1. Assuming they are able. But the Drug, GHB has had many great success stories. And of course many no-so-great. Please investigate this Drug before ordering, requesting etc. This is not a Drug to be played with. Used properly it can be very effective. Or dangerous if used wrong. Always do your homework first.

SOURCES: (Providers Oversea's where you can find and order)
*NEW: Help with paying for your Narcolepsy medications
*Note:I have kept the brief list of possible providers of medications to the end of this article. But for GHB it is provided normally by companies that only supply compounds that are hard to find. And a very few  Antiaging companies that market GHB in other forms as well.
Therefore these links below are intended for GHB only.

Further note. if a source is "in" the United States, the provider may require a prescription.
Or some form of documentation that you will use GHB only under a doctors supervision. Which is sound advise. First make sure it is legal in your home state. Then seek a doctor who has knowledge of GHB.

To help everyone who visits the various pages of my web site I have listed two unique resources for locating doctors who have knowledge of medications, drugs such as these.
To find a doctor in your area and home state that may be able to help you with GHB please refer to my section entitled " 7. Providers of Over Sea's Medications ". And once there scroll down to the middle of that page until you reach two sections marked " NEW ". Called, " Practitioner Referral Listing " & " Physician Directory ". Between those two resources you should find a doctor in your area that has the knowledge of GHB that can prescribe it if they see fit. And will supervise the proper useage of it. I would normally just provide a link to those two resources so you could jump to the resources themselves. However in this case each is unique in their own right and I have made a brief description of each on that sections page. So please feel free to visit it.

*Note: Do Not contact supply sources without reading and reviewing "all" links. And doing your homework on the proper pre-cautions and the correct use of GHB. And I would not recommend using without first visiting a doctor who has knowledge of the drug. And who will supervise your useage. Under a doctors care who knows the drug well it is very safe normally. But without, it can be dangerous for the inexperienced user.


A.) International Antiaging Systems, Ltd  B.) Laborit's List of GHB resources
C.) Smart-Publications (sources)              D.) Ghb providing sources                      E.) Lab-Tech

THE LAW & GHB:

NOTE: This is by no means a complete resource for legal areas surrounding "GHB".  Always seek advice of legal counsel before presuming to be in the "legal right". Nothing listed here is meant to be used as legal advice.


Legal Status and Availability:
GHB is not a approved medication by the FDA in the US,  and has been banned from over the counter sale by the FDA.  GHB has not yet been scheduled as a controlled substance by the DEA, and therefore simple possession is not necessarily illegal. GHB continues to be sold to legitimate laboratories and scientists for research purposes, but selling it specifically for human consumption, especially while making claims about its health benefits, is a violation of current FDA regulations and policy.  (Reference link click here)
Some legal reference links: *These links are not to be used as in place of legal advice.
A.) Erowid GHB Legislation Page                   B.) CERI: Reaction concerning Laws, and GHB
C.) GHB; Law Index; US States                        D.) Erowids GHB Legal Resources Page
E.) GHB Report to the California Legislature

Return to Introduction Page