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Whats the theory this month?

Well, it seems another possible answer has been found.
Perhaps more so a variation of a few former theories.

Let's look it this by examining a few links, and a
brief few descriptions. That way we can simply use
the words of the experts. Since it has become difficult
and time consuming to constantly research and link
the newest theory every three to six months.

As of January 12th, 2000. This is the "latest" theory.

* Missing Protein Linked to Narcolepsy

Reuters - December 31, 1999

NEW YORK, Dec 31 (Reuters Health) -- A protein normally found in spinal fluid appears to be lacking in many patients with the sleep disorder narcolepsy, according to a new
study.

The findings suggest that the protein, called hypocretin 1, could play a role in treating the ailment, which causes sudden sleep attacks that can occur many times a day.

"We now know that hypocretin 1 is involved in narcolepsy in humans, and if we supplement hypocretin 1 we may be able to dramatically improve the symptoms of the disorder," Dr. Seiji Nishino said in an interview with Reuters Health.

"We also know where to look in the human brain and how to study hypocretin 1," he said. "If we find (hypocretin 1's) mechanism, we may be able to prevent (narcolepsy) and cure the disease."

Nishino and colleagues from Stanford University compared the amount of hypocretin 1 found in the spinal fluid of nine individuals with narcolepsy and eight healthy individuals. In a research letter in the January 1st issue of The Lancet, they report that hypocretin 1 was "undetectable" in seven of the nine narcolepsy patients but was seen in all of the other individuals.

Nishino believes that the findings can be used to help diagnose narcolepsy. It is estimated that 1.6 people per thousand in Europe, Japan and the United States are affected by the disorder, which is usually treated with stimulants and antidepressants.   SOURCE: The Lancet 2000;355:39-40.



RELATED LINKS:

Stanford University Sleep Clinic

"Presynaptic and postsynaptic actions and modulation of
neuroendocrine neurons by a new hypothalamic peptide,
hypocretin/orexin"

The Lancet

Reuters Health

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