The sociabilisers are a novel class of molecules, whose properties were discovered by the author, and which could revolutionise the treatment of diverse psychopathologies. In these psychopathologies I am including the high level of undesirable intra-specific aggression found in the human species. Man has been unable to control his unwanted base-line paranoia and intra-specific aggressivity even with such a powerful ideology such as Christianity. The sociabilisers promise to reach, at last, such a control of these highly undesirable behaviours. The future of mankind is in enhancing sociability, first by sociabilising molecules, then through a new science (not yet in existence) called Neuromorphogenetics. The definitive enhancement of sociability in man is a desirable step for our descendants as this will promote cooperation between individuals instead of a totally useless and destructive intra-specific aggression. Man has suffered since his origin from his absurd intra-specific aggression, a heritage of his animal origin, of his present-day bestiality. Intra-specific aggression should be eradicated in order to make "human" beings really human beings and not sheer tallking and vociferous animals. The study of the Sociabilisers is the first step in this important direction. Christianity has failed to change the intra-specific aggression behaviour of man because this very primitive behaviour is deeply entrenched in the human CNS. Men (especially males and this applies equally to male scientists!) have a propensity to aggress each other and to establish a pecking-order, like all animals. But this primitive entropic behaviour is no longer in accordance with technological societies. In advanced technological societies we need highly sociable individuals. Where, for obvious reasons, Christianity has failed, Science will, probably, succeed! When intra-specific aggression will be only a foregone memory of the primitive Barbarians we are just now, then we can predict a bright future to our descendants. The discovery of the Sociabilisers is just, then, the beginning of a formidable behavioural revolution. One day wars and misery will be seen only as the consequences of a primitive faulty brain created by accident and not by a rational will.
The first sociabiliser was invented in France,in 1961: Gamma-OH or gamma-hydroxybutyrate. Gamma-OH was invented by Laborit and Wermuth when Laborit was thinking of creating a GABA analog which could penetrate through the brain-blood barrier. He talked about this with Wermuth and Wermuth came with gamma-hydroxybutyric acid. At that time nobody knew that this discovery was potential gold for the study of human behaviour and intra-specific aggression. Three class of sociabilisers have been now defined:
Since the discovery of Gamma-OH,in France,the French were unable to classify this molecule under anything known and so the classification of Gamma-OH has been rather erratic! It was, first, a hypnotic. Then it became a pre-anaesthetic and, now, it became an anti-addictive medicine for alcoholism!!! It may or may not become also an anti-addictive against opiate intoxication, as shown in Italy. After about 15 years of studying this molecule I finally arrived at the conclusion that Gamma-OH was the first molecule in a serie of novel molecules to be correctly called the sociabilisers (Sociabilisants, en français) because they act by enhancing sociability.
Experimenting with both Gamma-OH and MDMA, on myself and volunteers, I soon discovered that these two molecules had subjectively indistinguishable actions on sociability though the sociabilising action of MDMA is first masked because of its serotonin releasing property which is subjectively quite similar to the effects of fluvoxamine (the first specific serotoninergic reuptake blocker which was successfully put on the market) on consciousness and behaviour.
When human beings interact on increasingly friendly terms, natural base-line paranoia progressively disappears to be replaced by a feeling of intense pleasure, which is the result of social interaction. The lower natural paranoia becomes, the more sociability intensifies. Theory demonstrates that such consciousness states as "love" or "mystical" states are only states of exceedingly low paranoia and of progressively intensified sociability. In fact,there seems to be a "circuit of paranoia" in the CNS which would generate both paranoia and sociability, depending on how it is activated. Hyperactivation of this system would generate paranoid states while hypoactivation would generate sociable states, from love to mystical states. It is thus hypothesised that depressing paranoia (naturally or pharmacologically) leads automatically to increased sociability (probably through oxytocinergic neuromediation, etc) while increasing paranoia (like with pentazocine, phenylisopropylamines) leads to asociability and some psychopathologies such as paranoid schizophrenia,the competitive spirit of business men, etc. Modulating the sociability states of human beings can represent a powerful therapeuthics in depression and in the suppression of anxiety or suppression of the negative symptoms of schizophrenia. For instance, depression arises when sociability is decreased: intensifying sociability will thus have a thymoanaleptic (anti-depressant) effect. This is demonstrated by the powerful thymoanaleptic properties of Gamma-OH. Unfortunately for depressed patients, and because of the imipraminomimetic dogma, the thymoanaleptic properties of Gamma-OH remained essentially crypto-thymoanaleptic properties until the author discovered the remarkable effects of gamma-hydroxybutyrate on depression! Sociabilisers will probably throw most SSRIs to the wastebasket once they are fully developed! How many lives could have been saved had the research on anti-depressants not stayed confined on the invention of imipraminomimetics only. The present working hypothesis on the mechanism of action of sociabilisers is that they depress paranoia, as we noticed, thus leading, as natural sociability, to a vast array of potentially useful therapeutic effects. From the effects of natural (non-pharmacological) sociability it can be predicted that full sociabilisers should have the following properties:
Claude (Bângkoc et Tôkiô,Siam et Japon)
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